Development of genetically modified/engineered cell lines has enabled the expression of single receptor subtypes. This led to designing of receptor assays for surface-bound receptors. Receptors assays can be used to identify new ligands based on receptor activity. For instance, autophosphorylation of specific target proteins on tyrosine kinase receptors can be used to titrate known proteins like growth factors. Receptor based assays have been used for drug discovery and development for more ... Read more
