The stimulation of µ-opioid receptors in brainstem respiratory centers on the surface of the neuron leads to opioid-induced respiratory depression. The group of interneurons in the ventral respiratory group of the medulla of the brainstem which is known as the pre-Bötzinger complex (preBötC). The preBötC and parabrachial nucleus both involved in the expression of opioid receptors and respiratory pattern generation. An opioid overdose or combination use of opioid with other centrally ... Read more