Antisense oligonucleotides are synthesized short DNA or RNA strands that bind to messenger RNA (mRNA) and prevent protein synthesis by either degrading the target mRNA or blocking its translation. These oligonucleotides are used to treat rare diseases caused by single-gene mutations such as Duchenne muscular dystrophy and spinal muscular atrophy. The global antisense oligonucleotides market is estimated to be valued at US$ 2913.5 Mn in 2023 and is expected to exhibit a CAGR of 7.1% over the ... Read more

What are Antisense Oligonucleotides?
Antisense oligonucleotides (ASOs) are short engineered nucleic acid sequences designed to specifically bind to target messenger RNA (mRNA) molecules and interfere or "silence" gene expression. ASOs are generally 15-25 nucleotides in length and are chemically modified to increase their stability and binding affinity for mRNA. By binding to mRNA, ASOs can block translation and effectively decrease or silence the production of a target disease-causing ... Read more