Aldosterone receptor antagonist drugs are also known as MRAs, MCRAs, and anti-mineralocorticoids. Aldosterone receptor antagonist drugs are a drug class that inhibit the effects of aldosterone. Adrenal cortex of the adrenal gland produces a primary mineralocorticoid hormone, called aldosterone, in the body. Aldosterone increases sodium reabsorption by the colon, sweat glands, salivary glands, and kidneys. Aldosterone also increases excretion of potassium and hydrogen ions.