Miscarriage is a very heartbreaking event for both parents. Repeated miscarriage is not a very common incidence.  But approximately 1% to 2% of couples have experienced such problem during their family building. Usually, our society is always blaming females for such incidence. But a new medical research finding may change this outlook.

A recent research finding published in 24th March 2019 in the Endocrine Society's annual meeting in New Orleans, La reported that sperm DNA damage could be a responsible factor for recurrent miscarriage and in such cases female partner not be a cause of such issues.

Repeated pregnancy loss can be defined as the recurrent loss of pregnancy three or more times before reaching 20 weeks gestational period. In such cases, the female partner experienced multiple medical tests to identify the underlying cause. But in many cases, no definite findings identified.

Yet now, no male partner has to undergo any medical assessment to check if the male-factor play any role for such events. But medically it has proven that sperm obtained from male partner take part an important role in placenta formation, which is a vital necessity for fetus survival.  

Sperm DNA damage is one of the identified cause of fertility impairment. But yet now, no research has estimated that this may be the cause of repeated pregnancy loss. The aim of the recently conducted research was to evaluate the male partner of the affected woman may be a reason for repeated pregnancy loss.

In this research study, a number of male-factors such as testosterone level measurement, microscopic analysis of sperm number and their behavior and molecular tests of sperms had compared between the men whose partners had not experienced miscarriages with men whose partners were affected by repeated pregnancy loss.

Furthermore, in this study, it had also tested the intensity of sperm DNA damage and the concentration of reactive oxygen species ( ROS, free radicals). Increase level of reactive oxygen species can damage different body tissue, including sperm cells in the male members.

This study result showed that men whose partners were affected by repeated pregnancy loss had two times greater sperm damage than the unaffected men. This test result also reported that affected men had four times more reactive oxygen species than the unaffected men. 

The researchers of this study suggested that it is better to evaluate the male-factors also in case of women who are repeatedly experiencing a miscarriage.

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 This research also opens a door for pharmaceutical R&D department to formulate drugs for the treatment of sperm DNA damage, so that proper treatment given to the couples can reduce such mishaps.