Poly (ADP-ribose) polymerase (PARP) inhibitors are novel class of drugs developed to treat BRCA gene related cancers. It works by blocking the action of PARP enzyme that helps DNA repair mechanism. Without this repair DNA damage accumulates in cancer cells leading to their death. The global PARP Inhibitor Market is estimated to be valued at US$ 6.13 Bn in 2023 and is expected to exhibit a CAGR of 6.8% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.

Market Dynamics:

Rising incidences of cancer and growing demand for targeted therapy options are the major drivers of PARP inhibitor market growth over the forecast period. According to WHO, cancer burden has risen to 18.1 million new cases and 9.6 million cancer deaths in 2018. Further, growing clinical pipeline products and recent FDA approvals are fueling the market growth. For instance, in 2018 FDA approved Lynparza by AstraZeneca and Merck for germline BRCA mutated, HER2 negative metastatic breast cancer in post menopausal patients who have undergone previous chemotherapy. Additionally, continuous R&D investments by key players for advanced targeted cancer treatment are further propelling the market growth over the next few years. However, high cost of cancer treatment and therapy options remains a major challenge.

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SWOT Analysis

Strength: Parp inhibitor drugs have shown promising results in clinical trials for breast cancer and ovarian cancer treatment. Three main PARP inhibitor drugs Lynparza, Zejula and Rubraca have received FDA approval in recent years for certain types of breast and ovarian cancers with BRCA1 and BRCA2 mutations.

Weakness: PARP inhibitors have relatively higher costs and side effects compared to conventional chemotherapy drugs. High development costs and long regulatory approval timelines are other weaknesses. PARP inhibitors also work best for cancers with specific genetic mutations which limits their patient eligibility.

Opportunity: Ongoing clinical trials are exploring effectiveness of PARP inhibitors for other cancer types like prostate cancer, pancreatic cancer and various early stage cancers. Combination therapies with other drugs also have potential to expand use of PARP inhibitors. Increasing cancer incidence globally with growing demand for personalized cancer care provides opportunities.

Threats: Development of resistance to PARP inhibitors remains a challenge. Existing competition from other novel drugs and future pipeline of alternative targeted therapies are threats. Regulatory hurdles and reimbursement issues vary globally impacting market adoption.

Key Takeaways

The Global PARP Inhibitor Market Demand is expected to witness high growth.

Regional analysis: North America currently dominates the market due to early approvals and higher adoption of Lynparza, Zejula and Rubraca. Europe and Asia Pacific regions are also expanding significantly with increasing research.

Key players operating in the PARP inhibitor market are F. Hoffman-La Roche Ltd, Tesaro Inc, Clovis Oncology, Pfizer, and AstraZeneca. These leading players are focused on expanding clinical trials into additional cancer types and exploring combination therapies to address resistance issues and expand patient population.

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