Over time, significant strides have been made in immune checkpoint research, resulting in the discovery of several inhibitory (LAG-3, TIM-3, TIGIT, VISTA and B7-H3) and stimulatory receptors (OX40, ICOS, GITR, 4-1BB and CD40), which are being investigated as potential targets for therapy development. Further, studies of combinatorial immune checkpoint blockade / co-stimulation, targeting newly identified checkpoints along with known checkpoint inhibitor therapies, have demonstrated promising clinical outcomes as well.

 

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The USD 12 billion (by 2030) financial opportunity within the next generation immune checkpoint modulators market has been analyzed across the following segments:

Target Disease Indication 

• Breast Cancer
• Chronic Lymphocytic Leukemia
• Colorectal Cancer
• Head and Neck Cancer
• Lung Cancer
• Lupus Nephritis
• Melanoma
• Multiple Myeloma
• Primary Sjögren's Syndrome
• Others 

 

Target Immune Checkpoint

• B7-H3
• CD38
• CD40
• CD47
• Others

 

Mechanism of Action

• Inhibitory
• Stimulatory

 

Therapeutic Modality

• Monoclonal Antibody
• Small Molecule

 

Type of Therapy 

• Monotherapy 
• Combination Therapy

 

Route of Administration

• Intravenous
• Subcutaneous
• Others

 

Key Geographical Regions 

• North America
• Europe
• Asia-Pacific and the Rest of the World 

 

The Next Generation Immune Checkpoint Inhibitors and Stimulators Market, 2020-2030report features the following companies, which we identified to be key players in this domain:

Bristol Myers Squibb

GlaxoSmithKline

Incyte

Novartis

Trillium Therapeutics

 

Table of Contents

 

1. Preface

2. Executive Summary

3. Introduction

4. Current Market Landscape: Clinical and Preclinical Molecules

5. Market Landscape: Therapies Targeting Cd47

6. Market Landscape: Therapies Targeting 4-1bb

7. Clinical Trial Analysis 

8. Company Profiles: Next Generation Inhibitors and Stimulators

9. Academic Grants Analysis

10. Partnerships and Collaborations

11. Target Competitiveness Analysis

12. Big Pharma Initiatives

13. Market Forecast and Opportunity Analysis

14. Concluding Remarks

 

15. Executive Insights

 

16. Appendix 1: Tabulated Data

 

17. Appendix 2: List of Companies and Organizations

 

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Contact Details

Gaurav Chaudhary

+1 (415) 800 3415

gaurav.chaudhary@rootsanalysis.com