High-intensity focused ultrasound (HIFU) therapy is a novel, emerging, and therapeutic modality technology. It involves propagation of ultrasound waves through cancerous tissues that kills cancer cells. HIFU is a minimal invasive technique and is performed with real-time imaging by ultrasound or MRI to enable treatment targeting and monitoring. This technology have been extensively exploited for the treatment of prostate, liver, pancreatic, and bladder cancer.